Analisis Interaksi Aliran Darah dan Pembuluh Serta Pengaruh Kebebasan Mesh Pada Simulasi Hemodinamik Berbasis Metode Elemen Hingga

Cardiovascular diseases are the world’s leading cause of death with significant death rates caused by abnormalities in vessels such as aneurysms and stenosis. These conditions can potentially cause blockage and thinning of vessels which may lead to heart attack, stroke, and bleedings. Recently, computational simulation methods are frequently used in blood flow analysis. These methods are frequently used in vascular fluid dynamics analysis which relate to the origin of a disease, efficacy prediction in installation of therapeutic instruments and complements the in vitro studies. This article presents an example of a simple vascular simulation to study the effect of blood flow with respect to vascular wall displacement. Furthermore, this research shows the importance of formal CFD pre-processing such as mesh independence testing which influences the simlation accuracy as well as vascular flow prediction and its effects on vascular wall displacement. In this research, it is concluded that the number of mesh elements affects the accuracy of vascular wall shear stress (WSS) calculations with average WSS difference of 0.8 Pa with no significant difference in wall displacement values. An average WSS of 1.95 Pa and a wall displacement of 5.7 µm are obtained from the blood flow simulation in this study

Microscopic motility of isolated E. coli flagella

The fluctuation-dissipation theorem describes the intimate connection between the Brownian diffusion of thermal particles and their drag coefficients. In the simple case of spherical particles, it takes the form of the Stokes-Einstein relationship that links the particle geometry, fluid viscosity, and diffusive behavior. However, studying the fundamental properties of microscopic asymmetric particles, such as the helical-shaped propeller used by $\textit{E. coli}$, has remained out of reach for experimental approaches due to the need to quantify correlated translation and rotation simultaneously with sufficient spatial and temporal resolution. To solve this outstanding problem, we generated volumetric movies of fluorophore-labeled, freely diffusing, isolated $\textit{E. Coli}$ flagella using oblique plane microscopy. From these movies, we extracted trajectories and determined the hydrodynamic propulsion matrix directly from the diffusion of flagella via a generalized Einstein relation. Our results validate prior proposals, based on macroscopic wire helices and low Reynolds number scaling laws, that the average flagellum is a highly inefficient propeller. Specifically, we found the maximum propulsion efficiency of flagella is less than 5%. Beyond extending Brownian motion analysis to asymmetric 3D particles, our approach opens new avenues to study the propulsion matrix of particles in complex environments where direct hydrodynamic approaches are not feasible.Comment: 6 pages, 4 figures, 9 supplemental sections, 7 supplemental figures, 3 supplemental movies *authors contributed equally and reserve the right to change order for first authorshi

PERANCANGAN APLIKASI KONSULTASI PSIKOLOGI MANDIRI UNTUK KESEHATAN MENTAL YANG OPTIMAL MENGGUNAKAN METODE COLLABORATIVE DESIGN

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Analisis Interaksi Aliran Darah dan Pembuluh Serta Pengaruh Kebebasan Mesh pada Simulasi Hemodinamik Berbasis Metode Elemen Hingga

Cardiovascular diseases are the world’s leading cause of death with significant death rates caused by abnormalities in vessels such as aneurysms and stenosis. These conditions can potentially cause blockage and thinning of vessels which may lead to heart attack, stroke, and bleedings. Recently, computational simulation methods are frequently used in blood flow analysis. These methods are frequently used in vascular fluid dynamics analysis which relate to the origin of a disease, efficacy prediction in installation of therapeutic instruments and complements the in vitro studies. This article presents an example of a simple vascular simulation to study the effect of blood flow with respect to vascular wall displacement. Furthermore, this research shows the importance of formal CFD pre-processing such as mesh independence testing which influences the simlation accuracy as well as vascular flow prediction and its effects on vascular wall displacement. In this research, it is concluded that the number of mesh elements affects the accuracy of vascular wall shear stress (WSS) calculations with average WSS difference of 0.8 Pa with no significant difference in wall displacement values. An average WSS of 1.95 Pa and a wall displacement of 5.7 µm are obtained from the blood flow simulation in this study